![]() Mounting evidence has indicated that CP is a risk factor for aspiration pneumonia, chronic obstructive pulmonary disease, diabetes, and pre-term birth ( 1, 2). Severe CP can result in the loosening of teeth, occasional pain, periodontal bone loss, and eventual tooth loss ( 1, 2). Conclusion: BA in saliva may play a role in EBV reactivation and hence contribute to EBV-related disease progression in CP patients.Ĭhronic periodontitis (CP) is a complex chronic inflammatory microbial disease that is prevalent in humans worldwide ( 1, 2). As expected, CP patients' saliva induced AcH3. Among SCFAs, BA alone correlated significantly with the BZLF1 transcription (r=0.88 p<0.02). Results: BZLF1 mRNA expression and transcriptional activity in EBV-infected Daudi cells were induced only when treated with the CP saliva. Histone H3 acetylation (AcH3) was further examined. BZLF1 mRNA and its pertinent protein ZEBRA were determined with Real-time PCR and western blotting. Materials and Methods: Saliva was collected from seven CP patients and five periodontally healthy individuals. We investigated whether short chain fatty acids (SCFAs) in CP patients' saliva enabled EBV reactivation. ![]() ![]() We previously demonstrated that butyric acid (BA), produced by periodontopathic bacteria, induced EBV lytic switch activator BZLF1 expression. Background/Aim: Epstein-Barr virus (EBV) associates with human chronic periodontitis (CP) progression. ![]()
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